Pathogenic Pore-Forming Proteins: Function and Host Response
نویسندگان
چکیده
منابع مشابه
Pore-forming peptide of pathogenic Entamoeba histolytica.
A polypeptide that causes pore formation in target-cell membranes is implicated in the potent cytolytic activity of pathogenic Entamoeba histolytica. Pore-forming material was purified to apparent homogeneity by a multistep procedure, and its analysis by NaDodSO4/PAGE revealed one peptide of 4-5 kDa under nonreducing or under reducing conditions. Pore-forming activity was measured by depolariza...
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Crystallographic studies of the past ten years have revealed that many outer membrane proteins and bacterial toxins are constructed on the b-barrel motif. Two structural classes can be identified. The first class, represented by the porins, includes monomeric or multimeric proteins where each b-barrel is formed from a single polypeptide. The second class features proteins where the b-barrel is ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2012
ISSN: 1931-3128
DOI: 10.1016/j.chom.2012.08.005